Annual Global Survey Data

The WFH Annual Global Survey data includes selected demographic and treatment data on people with hemophilia, von Willebrand disease, rare factor deficiencies, and inherited platelet disorders throughout the world. The WFH thanks our national member organizations for their help in gathering this important data. The interactive graphs accessible on this page are based on WFH Annual Global Surveys from 1999 to 2017.

Map of Bleeding Disorders

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With the Patients per 100,000 option, 0 means < 1 patient per 100,000 people.

Disclaimer: This graph demonstrates the number of patients reported in the specific year. Not all of our members are able to report every year. A list of participating countries and the last year they provided data can be found in the Report on the Annual Global Survey of the years shown.

Where there is no color on the map, no data were reported by the country for that year.

Identified Patients with Bleeding Disorders -

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Disclaimer: This graph uses data for the years shown. Not all of our members are able to report every year. A list of participating countries and the last year they provided data can be found in the Report on the Annual Global Survey

Where there is no graph for a bleeding disorder, no data were reported by the country for that year.

Distribution of Bleeding Disorders -

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Other Bleeding Disorders (OBD) Includes

  • Factor I deficiency
  • Factor II deficiency
  • Factor V deficiency
  • Factor V+VIII deficiency
  • Factor VII deficiency
  • Factor X deficiency
  • Factor XI deficiency
  • Factor XIII deficiency
  • Other hereditary bleeding disorders: type unknown
  • Glanzmann thrombasthenia
  • Bernard Soulier syndrome
  • Platelet disorders: other or unknown

Disclaimer: This graph uses data for the years shown. Not all of our members are able to report every year. A list of participating countries and the last year they provided data can be found in the Report on the Annual Global Survey.

Where there is no graph for a bleeding disorder, no data were reported by the country for that year.

Bleeding Disorders by Gender -

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Bleeding Disorders by Age Group -

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GNI(Gross national income per capita): High income (A): $12,616 or more, Upper middle income (B): $4,086 to $12,615, Lower middle income (C): $1,036 to $4,085, Low income (D): $1,035 or less, U= unknown

Hemophilia Patients by Severity -

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Severity defined by factor level: severe, ≤ 0.01 international units (IU); moderate, 0.01–0.05 IU; mild, >0.05 IU

GNI(Gross national income per capita): High income (A): $12,616 or more, Upper middle income (B): $4,086 to $12,615, Lower middle income (C): $1,036 to $4,085, Low income (D): $1,035 or less, U= unknown

Map of FVIII use per capita

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Note: Factor VIII per capita is used as a general indicator of levels of treatment because, in all care systems, it is proportionately the largest expenditure. The WFH has established that one international unit (IU) of FVIII clotting factor concentrate per capita should be the target minimum for countries wishing to achieve optimal survival for the hemophilia population. Higher levels would be required to preserve joint function or achieve a quality of life equivalent to an individual without hemophilia. Furthermore, some FVIII products are used in the treatment of von Willebrand disease and not exclusively for hemophilia A.

Disclaimer: Where there is no color on the map, no data were reported by the country for that year.

FVIII and FIX Use per Capita -

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The red line indicates 1 IU per capita of factor VIII. The WFH has established that one international unit (IU) of FVIII clotting factor concentrate per capita should be the target minimum for countries wishing to achieve optimal survival for the hemophilia population. Higher levels would be required to preserve joint function or achieve a quality of life equivalent to an individual without hemophilia.

The red line does not apply to factor IX. Where there is no number for factor IX, no number was reported.

Countries that did not provide data have been excluded from this chart.

FVIII and FIX use per capita over time -

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Identified Patients over time -

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The numbers represent total number of patients identified since 1999. That is, if a country reported one year and not after, the latest data was used under the assumption that the number of patients did not change substantially from one year to the next. This reflects an estimate of the total number of identified patients with inherited bleeding disorders.

Other Bleeding Disorders over time -

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The numbers represent total number of patients identified since 1999. That is, if a country reported one year and not after, the latest data was used under the assumption that the number of patients did not change substantially from one year to the next. This reflects an estimate of the total number of identified patients with inherited bleeding disorders.

Identified verus Expected Patients by Region

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Identified verus Expected Patients by Country in Region - GNI

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Country Profile:

Annual Global Survey

Identified patients over time

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The numbers represent total number of patients identified for the selected time frame. That is, if a country reported one year and not after, the latest data was used under the assumption that the number of patients did not change substantially from one year to the next. This reflects an estimate of the total number of identified patients with inherited bleeding disorders.

Percent of identified patients - vs regional comparison

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The percentage of expected vs. identified number of patients. This chart compares the selected country to the countries within the same region. The expected number of patients is calculated based on the prevalence of 21 per 100,000 males as estimated by Iorio et al. (2019).

Distribution of bleeding disorders

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Hemophilia patients by severity

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Mean IU per capita over time -

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Mean IU FVIII per capita - vs regional comparison

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Mean IU FIX per capita - vs regional comparison

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Participation in the Annual Global Survey is voluntary. The numbers in this Country Profile are as reported by our national member organizations. They are not independently verified by the WFH. Fluctuation in numbers over time can reflect a change in the data collection system for the country. Missing or discrepant values are due to missing or incomplete submission of the questionnaire.

The AGS country profiles are developed under the supervision of the WFH Data & Demographics Committee.

The expected number of patients is calculated based on the prevalence of 21 per 100,000 males as estimated by Iorio et al. (2019)

To access the full Report on the Annual Global Survey, please visit: http://www1.wfh.org/publications/files/pdf-1714.pdf
For additional information and data, please visit https://www.wfh.org/en/data-collection